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BRUSSELS — Nearly two years into the COVID-19 pandemic, the world raced Friday to contain a new coronavirus variant potentially more dangerous than the one that has fueled relentless waves of infection on nearly every continent.

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Most people in Adams, Arapahoe and Jefferson counties must wear a mask indoors beginning Wednesday, the boards of health for the counties voted Monday, and Denver officials say they will hold a press conference on their own mitigation measures Tuesday.