Rampart will host No. 3 Mountain Vista on Tuesday in the round of 16.
The Rams (19-5) outscored George Washington (19-6) in every quarter, including pouring it on in the fourth quarter with 21 points.
Cassidy Budge scored a team-high 18 points, while Nicea Eliely posted a double-double with 11 points and 12 rebounds. Victoria Mondy added nine points and a team-high 13 rebounds.
Lakewood 62, Doherty 31
At Lakewood: No. 2 Lakewood (23-1) cruised into the round of 16 with a 31-point win over No. 7 Doherty (11-13).
Jessica Brooks posted a double-double with a team-high 18 points and 10 rebounds, and Gabby Carbone added 11 points for the Tigers. Lakewood jumped out to a 30-12 lead at the half and Doherty never recovered.
Palmer Ridge 57, Weld Central 36
At Glenwood Springs: A year after a trip out west went poorly, No. 3 Palmer Ridge (20-3) cruised past No. 6 Weld Central (17-7) by 21 points.
The Bears next take on host No. 2 Glenwood Springs, winners over Golden.
Last season, the Bears, again seeded third, lost to Rifle at Montrose.
Sand Creek 66, Mead 43
At Sand Creek: The No. 1 seed in the Tanya Haave Region jumped out to a 35-18 lead at the half, then added another 20 points in the third quarter, as Sand Creek (21-3) put away No. 8 Mead (15-10).
On Saturday at 3 p.m., the Scorpions host No. 5 Evergreen, upset winners over No. 4 Windsor.
Valor Chr. 64, Falcon 44
At Valor Christian: No. 2 Valor Christian (21-3) held off No. 7 Falcon (12-13) to advance to Saturday's round of 16.
But the Falcons didn't make it easy. After falling behind 33-18 at the half, the Falcons cut it to seven in the third quarter.
"We just couldn't sustain a run," Falcon coach Rick Susak said.
The Falcons also committed 27 turnovers in the loss.
Harmony Pettis led the Falcons with 16 points, and Kayla Travis added 13 and five assists.
D'Evelyn 55, Canon City 47
At D'Evelyn: Canon City's season came to an end, though the No. 7 Tigers (12-13) hung with No. 2 D'Eveyln (20-4).
No stats were reported by press time.
Elizabeth 58, Air Academy 45
At Elizabeth: No. 2 Elizabeth (22-2) handled Air Academy's (13-11) pressure defense to advance to Satuday's round of 16.
3A TRI-PEAKS TOURNAMENT
Manitou Springs 38, Trinidad 28
At Manitou Springs: Manitou Springs (15-6) jumped out to a 25-14 lead at the half on Trinidad (15-6) and then held on for the win to advance to the league championship.
Manitou Springs will play Lamar in the league final.
Lamar 57, St. Mary's 41
At St. Mary's: Lamar (21-0) scored 24 points in the first half while holding St. Mary's (14-8) to single digits in each of the first two quarters to advance to Saturday's league title game.
The Classical Academy 53, La Junta 32
At TCA: Three players hit the double-digit mark, including Hannah Carr who posted a double-double with 11 points and 11 rebounds, as TCA (16-6) advanced to a league consolation game.
Courtney Giggs led the Titans with 13 points and Leah Hinckfoot added 12 for the Titans.
2A District 8 tournament
Peyton 64, Vanguard 41
At Peyton: Shelby Patterson scored 21 points and Emily Green added 10, as Peyton (20-1) knocked off the Vanguard School (16-5) to advance to the district title game.
Peyton will play Simla for the district title.
Simla 40, Calhan 29
At Simla: Simla (18-3) held off Calhan (8-12) to advance to Saturday's district championship game against Peyton.
Cheyenne Mountain 66, Silver Creek 57
At Cheyenne Mountain: Behind Reece Eddy's 22 points and Ghassan Nehme's 21, No. 2 Cheyenne Mountain (19-5) held off an upset bid by No. 7 Silver Creek (13-12) to advance to Saturday's third round of the 4A state playoffs.
The Indians play again Saturday at 3 p.m.
Air Academy 69, Durango 47
At Valor Chr.: No. 5 Air Academy (19-6) made sure its matchup with No. 4 Durango (15-7) wasn't close at all.
Using tight defense and a transition game to capitalise, the Kadets () led by 30 after three quarters to cruise into the third round of the playoffs.
They'll face No. 1 Valor Christian on Saturday at 7:30 p.m.
Stephen Heard and Bobby Davis each scored 16 points and James Sims added 13 for Air Academy, which shot 58 percent from the field.
"We're playing our best basketball of the year by far right now," Kadets coach Barry Clark said. "This is the right time to play them."
The Kadets held Durango to five points in the third quarter.
"We did the same, we just played team defense the whole time and they were able to grind out the 30 points we needed and it pushed us over the top," Clark said. "I don't know if it was anything special."
D'Evelyn 75, Falcon 69
At D'Evelyn: No. 8 Falcon (14-11) came extremely close to being the first team to eliminate a No. 1 seed this season, battling until late in the fourth quarter before falling to D'Evelyn (19-5).
Pueblo South 55, Palmer Ridge 47
At Pueblo South: No. 1 Pueblo South (22-2) proved to be too much for No. 8 Palmer Ridge (14-11), which hung around enough to put a scare into the Colts.
Sand Creek 64, Steamboat Springs 49
At Sand Creek: No. 2 Sand Creek (19-5) cruised past No. 7 Steamboat Springs (18-7) to advance to Saturday's round of 16.
The Scorpions will host No. 3 Denver West at 5 p.m.
3A Tri-Peaks tournament
CSCS 66, Ellicott 40
At CSCS: Ellicott (11-4) gave CSCS (17-3) everything it could handle, even leading by a point at the half.
But Sam Howard and company went to work in the paint. Howard scored 17, Justin Engesser added 13 and CSCS reached the 3A Tri-Peaks tournament final.
The Lions will play Manitou Springs at CSCS on Saturday at 8:30 p.m.
The Lions outscored Ellicott 22-5 in the third quarter and 20-10 in the fourth to pull away.
Manitou Springs 46, St. Mary's 36
At St. Mary's: Manitou Springs (11-10) made the most of a rivalry revenge game.
The Mustangs lost to rival St. Mary's (17-4) way back in mid-December. What better way back than to defeat your rival in the league semifinals.
Chase Megyeri scored a game-high 23 points and Manitou Springs advanced to take on CSCS in Saturday's final. The Mustangs rallied from a 10-point deficit after the first quarter.
Connor Gosselin scored 13 points to lead St. Mary's.
The Classical Academy 59, James Irwin 42
At TCA: The Classical Academy (12-10) used a 21-10 fourth quarter to put the game out of reach against James Irwin (13-8) and advance to a league consolation game.
The Titans will play Florence on Saturday.
Will Ball had an impressive double-double with 27 points and 16 rebounds, plus he added three steals and five blocks. Davey Haddad scored nine points, had eight steals and five assists.
2A District 8
Calhan 44, Peyton 40
At Peyton: Calhan (10-11) knocked off rival Peyton (18-3) to advance to the district championship, where the Bulldogs will take on Simla on Saturday.